Below is a small list of some of the worst mass killing in Northern America:1539 Napituca Massacre:

1541-42 Tiguex Massacres: 250 killed

1599 Acoma Massacre: 800 killed

1601 Sandia Mountains Tompiro Indians massacre: 900 killed

1623 Pamunkey Peace Talks: the English poison wine at peace talks with Powhatan 250 killed

1637 Mystic Massacre: colonist set fire to Pequot village 600-700 killed.